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In healthy adults the total concentration sits around 200 to 600 pmol/L, but the upper reference limit varies by laboratory and by analytical platform

The ASM is activated by several cellular stresses implicated in both apoptosis and autophagy by modulating the balance between ceramide and its metabolic derivatives, sphingosine (Sph) and sphingosine-1-phosphate (S1P) (Lee et al., 2014)

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Hilger JA

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